Project Awards

Mi-TRAC and Mi-Kickstart awards are part of the University of Michigan MTRAC for Life Sciences Innovation Hub, a statewide program that supports translational research projects in life sciences with high commercial potential.

Mi-Kickstart early-stage funding awards are given quarterly and offer funding in the $25K-$50K range, with proposals due February 1, May 1, August 1, and November 1.

Mi-TRAC mid-stage funding awards are given once a year in January and offer funding in the $100K-$250K range, with proposals due in September.

We invite you to browse our portfolio of successful projects and faculty innovators.

Following is a list of Mi-Kickstart and Mi-TRAC awardees.

2017 STATEWIDE PROJECT AWARDS

Principal Investigator Proposal Budget Startup
Sean Ahlquist, M.Arch.
U-M – Assistant Professor of Architecture, A. Alfred Taubman College of Architecture and Urban Planning
Kinesthetic Environment for Sensory Regulation, Engaged Learning, and Social Interaction
John Anagli, Ph.D.
Henry Ford Health System – Research Department
Selective Calpain Inhibitor-based Treatment for Traumatic Brain Injury  $49,971
Jimo Borjigin, Ph.D.
UM – Physiology
Electrocardiomatrix (ECM): A New Method for Detection of Cardiac Arrhythmias  $126,100
Benjamin Buller, Ph.D.
Henry Ford Health System – Neurology
Commercialization of a Wide-Ranging Exosome Platform for Treatment of Stroke  $231,408
Mark Burns, M.S., Ph.D.
Chandu Vermuri, M.D., FACS

UM – Mechanical Engineering
UM – Vascular Surgery
UM – Emergency Medicine
UM – Michigan Center for Integrative Research in Critical Care
Microfluidic Device for the Measurement of Viscosity, Coagulation, and Red Blood Cell Deformability in Blood $150,567
Karim Essani, Ph.D.
Western Michigan University – Professor, Department of Biological Sciences
Oncolytic Tanapox Virus Recombinants for the Potential Immuno-virotherapy of Human Triple Negative Breast Cancer
Xudong Fan, Ph.D.
UM – Biomedical Engineering
UM – Emergency Medicine
UM – Michigan Center for Integrative Research in Critical Care
Micro Gas Chromatography and Breathomics for Acute Point-of-Care Diagnostics in Acute Lung Injury  $138,000
Craig Friedrich, Ph.D.
Michigan Technological University – Engineering
Erin Baker, Ph.D.
Beaumont – Orthopaedic Surgery
Antibacterial Orthopaedic Implant Commercialization  $183,672
James Geiger, M.D.
UM – Professor, Department of Surgery, Pediatric Surgery Section
Home Ventilator – Continuous CO2 Monitoring $42,450
Michael Holinstat, Ph.D.
UM – Associate Professor of Pharmacology and Internal Medicine, Department of Pharmacology
Analogs of ML355 for Inhibition of 12-LOX In Vivo Resulting in Prevention of Heparin-Induced Thrombocytopenia and Thrombosis
Michael Lanham, M.D.
UM – Obstetrics & Gynecology
OnTrack-Development and Evaluation of Software Medication Management Service for Infertility Patients  $232,712
Scott Larsen, Ph.D.
UM – Pharmacy
Rick Neubig, M.D., Ph.D.
Michigan State University – Pharmacology
Development of a Highly Potent Inhibitor of the Rho/MRTF/SRF Pathway as A Novel Oral Therapeutic for Scleroderma  $231,560
Sophia Merajver, M.D., Ph.D.
Matthew Soellner, Ph.D.
UM – Internal Medicine
Dual c-Src/p38 Inhibitor for Triple Negative Breast Cancer  $200,000
James Moon Ph.D.
Anna Schwendeman, Ph.D.
UM – Pharmacy
A Novel Nano-Vaccine Technology for Cancer Immunotherapy  $264,277
Ruthann Nichols, Ph.D.
U-M – Department of Biological Sciences
Novel Agent to Improve Cardiac Performance $50,000
Mukesh Nyati, Ph.D.
U-M – Associate Professor, Department of Radiation Oncology
EGFR Dimer Disruptor for TKI Resistant Cancers
Cyrus Piraka, M.D.
Henry Ford Health System – Section Chief, Advanced Therapeutic Endoscopy
Novel Device for Polyp Removal in the GI Tract  $29,412
Gus Rosania, Ph.D.
U-M – Pharmacy
Drug Repurposing for Gouty Arthritis $50,000
Lonnie Shea, Ph.D.
U-M – William and Valerie Hall Department Chair & Professor, Department of Biomedical Engineering
An Implanted Biomaterial Scaffold for Early Detection of Metastasis
Muneesh Tewari, M.D., Ph.D.
Nils Walter, Ph.D.
UM – Hematology/Oncology
UM – LSA/Chemistry
A High-Specificity, Direct Single Molecule Counting Technology to Enable Cell-Free DNA-Based Liquid Biopsy for Oncology  $200,000
James Varani, Ph.D.
UM – Pathology
Novel, Non-Irritating Retinoids for the Treatment of Acne  $137,971

2016 U-M MEDICAL SCHOOL PROJECT AWARDS

Principal Investigator Proposal Budget Startup
Cagri Besirli, M.D., Ph.D.
Ophthalmology
CryoAnesthesia – Rapid anesthesia for intraocular injections $224,661
Michele Carney, M.D.
Emergency Medicine
Positioning Device for Seated Neonatal Lumbar Puncture Procedure $25,000
Marilia Cascalho, M.D.
Surgery
Jeffrey Platt, M.D.
Microbiology & Immunology
C3D Cellular and Acellular Vaccines for the Prevention and Treatment of Cancer $49,950
Edward Castillo, M.A., Ph.D.
Beaumont Health, Radiation Oncology
A Novel Method for Detecting Pulmonary Embolism from Non-Contrast 4DCT $50,922
Bill Chey, M.D.
James Ashton-Miller, M.S.M.E.
Internal Medicine – Gastroenterology
Digital Manometry: A disposible, point-of-service diagnostic device for patients with fecal incontinence $104,802
Gabriel Corfas, Ph.D.
UM – Otolaryngology
Development of Small Molecule Positive Modulators of Ligand-Induced Ret Signaling as Treatment for Small Fiber Peripheral Neuropathy $50,847
Tim Cornell, M.D.
Pediatrics – Intensive Care
Michigan Center for Integrative Research in Critical Care
Development of a Near-Real Time Microfluidic Assay Device Reader for Identification of Targetable Cytokines in High-Risk Septic Patients $193,962  
Rodney Daniels, M.D.
Pediatrics – Critical Care
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Redox POC Platform for Evaluation and Treatment of Sepsis, Septic Shock, and Multiple Organ Dysfunction $155,434
Bogdan Epureanu, M.S., Ph.D.
Mechanical Engineering
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Therapeutic Vibration Device $25,000
Kate Fitzgerald, M.D.
Psychiatry
Automated brain “read-outs” for diagnosing anxiety and depression in preschoolers $35,000
Jim Geiger, M.D.
Saja Al-Duhaili, Ph.D.
Surgery – Pediatrics
BUDDY Button – Low-Profile Gastrostomy Device $150,000
Michael Holinstat, Ph.D.
UM – Pharmacology
Analogs of OxyProtect (12-HETrE) for inhibition of platelet function and thrombosis $50,000
Wenjun Ju, M.S., Ph.D.
Nephrology
Raymond Trievel, Ph.D.
Biochemistry
New drug development for chronic kidney disease $50,000
Helen Kales, M.D.
Psychiatry
WeCareAdvisor: A Novel Web-Based Tool to Assess and Manage Behavioral Symptoms of Dementia $208,457
Tyson Kim, M.D., Ph.D.
Ophthalmology
Smartphone-based Retinal Imaging for Screening of Eye Disease $132,847
Michael Lanham, M.D.
Obstetrics & Gynecology
OnTrack $50,000
Dan Lawrence, Ph.D.
Internal Medicine – Cardiology
Develop a Preclinical Data Package for a Small Molecule Inhibitor of PAI-1 $200,407
Yongqing Li, M.D., Ph.D.
Surgery
Targeting Peptidylarginine Deiminase: A Novel Approach to Treatment of Septic Shock $50,000
David Markovitz, M.D.
Internal Medicine – Infectious Disease
Treatment of influenza with a New Broad-Spectrum Antiviral Agent $259,291  
Sofia Merajver, M.D., Ph.D.
Public Health
Targeting RhoC to prevent metastasis $25,000
Kayvan Najarian, Ph.D.
Kenn Oldham, Ph.D.
Emergency Medicine
Mechanical Engineering
Computational Medicine & Bioinformatics
Michigan Center for Integrative Research in Critical Care
Dynamic Arterial Morphology Analysis for Prediction of Intradialytic Hypotension $50,000  
Zaneta Nikolovska-Coleska, Ph.D.
Pathology
Development of MCL-1 inhibitors as a targeted therapy to circumvent drug resistance in human multiple myeloma $181,936
Brent Nowak, Ph.D.
Grand Valley State University – applied Medical Device Institute (aDMI)
John Farris, Ph.D.
Grand Valley State University – Biomedical Engineering
Brent Mulder, Ph.D.
Spectrum Health Innovations
uCol – A Novel Female Urinary Collection Device For Reducing CAUTIs $49,194
Dipankar Ray, Ph.D.
Mukesh Nyati, Ph.D.
Christopher Whitehead, Ph.D.
Radiation Oncology
Therapeutic Targeting of mutant KRAS $199,795
Bruce Richardson, M.D., Ph.D.
Internal Medicine – Rheumatology
Anti-KIR Antibodies in the Treatment of Lupus $142,852
Jeff Sakamoto, Ph.D.
UM – Mechanical Engineering
Scale-able manufacturing of nerve guidance scaffold technology $50,000
Joshua Stein, M.D., M.S.
Ophthamology & Visual Sciences
Monitoring Patients with Glaucoma Using a Novel Personalized Forecasting Tool $31,000
Shuichi Takayama, Ph.D.
Biomedical Engineering, Macromolecular Science & Engineering
Jason Knight, M.D.
Rheumatology
Bioengineered NETs Diagnostic for Lupus Flares $50,000
Ashootosh Tripathi, Ph.D.
Life Sciences Institute
Ribosome Engineering for Improved Production of Novel Antibiotics against Uropathogenic E. coli $49,997
James Varani, Ph.D.
Pathology
New Leads for Promyelocytic Leukemia $50,000
J Scott VanEpps M.D., Ph.D.
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Chiroplasmonic Nanorod-PCR (NR-PCR) for rapid bacterial identification and antibiotic resistance testing in sepsis $52,050
Chao-Yie Yang, Ph.D.
UM – Hematology, Oncology
Development of in vivo chemical inhibitors to target the ST2/IL-33 axis for treating graft-versus-host disease $50,000
Suzanna Zick, N.D., M.P.H.
Public Health
Development and Feasibility of an Acupressure Application Tailored by Breast Cancer $49,676

2015 U-M MEDICAL SCHOOL PROJECT AWARDS

Principal Investigator Proposal Budget Startup
Ashwin Belle, Ph.D.
Rodney Daniels, M.D.
Kayvan Najarian, Ph.D.
Emergency Medicine
Pediatrics
Computational Medicine & Bioinformatics
Michigan Center for Integrative Research in Critical Care
Advanced Hemodynamic Assessment and Monitoring Using Computer-Aided Analysis of ECG Signals $184,601
Cagri Besirli, M.D., Ph.D.
Ophthalmology
Cryoanesthesia $30,000
Tiffany Braley, M.D., M.S.
Neurology
Dimethyl fumarate: a novel therapeutic agent for obstructive sleep apnea $208,902
Mark Burns, M.S., Ph.D.
Chemical Engineering
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Droplet-based Microfluidic Rheometer for Real-time Viscosity Monitoring of Blood Coagulation $25,000
Brian Byrd, M.D.
Internal Medicine
A Novel Biomarker of Mineralocorticoid Receptor Activation $25,000
Rodney Daniels, M.D.
Pediatrics
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Point-of-Care (POC) Platform for Small Volume Analysis of Blood and Body Fluid Redux in Illness and Injury $25,000
Alexis Donneys, M.D., M.S.
Plastic Surgery
Microscopic Video Surveillance Systems $24,897
Xudong Fan, Ph.D.
Biomedical Engineering
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Micro Gas Chromatography and Breathomics for Acute Point-of-Care Diagnostics $25,000
Jianping Fu, M.S., Ph.D.
Mechanical Engineering
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Development of A Microscale Whole Blood Coagulation Assay Platform $30,000
James Geiger, M.D.
Saja Al-Dujaili, Ph.D.
M-PED
Surgery
Low-Profile Gastrostomy Device $35,000
Todd Herron, Ph.D.
Jose Jalife, M.D.
Internal Medicine – Cardiology
Human Heart in a Dish: Novel In Vitro Cardiotoxicity Testing Platform $120,516
John Hollingsworth, M.D.
Urology
Stent Tracker $25,000
Michael Hortsch, Ph.D.
Cell and Developmental Biology
SecondLook™ – A Template for Interactive E-Learning Tools $25,000
Mark Ilgen, Ph.D.
Xudong Fan, Ph.D.
Psychiatry
Biomedical Engineering
Wearable Alcohol Monitoring Device $25,000
Thiran Jayasundera, M.D.
Ophthalmology & Visual Services
EyeAnalyze: Automated Identification and Quantification of Changes in Retinal Diseases $150,198
Alon Kahana, M.D., Ph.D.
Ophthalmology and Visual Sciences
Lacrimal Stent With Opening to Improve Draining Efficacy and Reduce Infection $33,000
Lisa Larkin, Ph.D.
Molecular and Integrative Physiology
Acellularization of Tissue Engineered Tendon Constructs for Rotator Cuff Repair $25,000
Michelle Macy, M.D.
Emergency Medicine
The Carseat Compass $35,000
David Markovitz, M.D.
Internal Medicine
H84T BanLec $39,000
Melvin McInnis, M.D.
Psychiatry
A Clinical Intervention Trial of Bipolar Disorder: Predicting Individual Outcomes for Rapid Intervention (PRIORI) $203,524
Kayvan Najarian, Ph.D.
Brahmajee Nallamothu, M.D.
Emergency Medicine
Internal Medicine – Cardiology
Computational Medicine & Bioinformatics
Michigan Center for Integrative Research in Critical Care
Computer-Aided System for Automated Analysis of Coronary Angiograms $102,995
Mukesh Nyati, Ph.D.
Theodore Lawrence, M.D.
Radiation Oncology
Targeting erlotinib resistant EGFR for degradation in lung and colorectal cancers. $189,448
Marc Peters-Golden, M.D.
Internal Medicine
Inhaled SOCS-containing liposomes for treatment of inflammatory lunch diseases $26,209
David Raffel, Ph.D.

 

18F-Hydroxyphenethylguanidine for PET Quantification of Cardiac Sympathetic Nerve Density in Patients with Ischemic Cardiomyopathy Undergoing ICD Implantation $179,445
Jonathan Rubin, M.D., Ph.D.
Radiology
Michigan Center for Integrative Research in Critical Care
Real-Time Ultrasound Measurement of Local Lung Ventilation $25,000
Michael Sabel, M.D.
Surgery
Development and implementation of clinical companion mobile technologies in health care. $125,968
Robert U. Simpson, Ph.D.
UM – Pharmacology
Peter Higgins, M.D., Ph.D.
UM – Gastroenterology
CARD-024 for Intestinal Fibrosis $28,497
Jess Thoene, M.D.
UM – Pediatrics
Demonstration of Delivery of Human Cystinosin Into Animal Cornea Via Microvesicles $24,500
James Varani, Ph.D.
Pathology
New Leads for Promyelocytic Leukemia $30,000
Nils Walter, Ph.D.
Muneesh Tewari, M.D., Ph.D.
Chemistry
Internal Medicine
A New Technology for Single Molecule Counting of Nucleic Acid Biomarkers $30,000
Christopher Whitehead, Ph.D.
Judy Leopold, Ph.D.
Radiology
EGFR and PI3K inhibitors: Design and Discovery of Dual Lipid and Receptor Kinase Inhibitors $199,647  
Matt Young, Ph.D.
Nicholas Donato, M.D., Ph.D.
Internal Medicine – Nuclear Medicine
Targeting deubiquitinases with small molecule inhibitors: A novel approach in cancer pathway and oncotarget inactivation $200,000

2014 U-M MEDICAL SCHOOL PROJECT AWARDS

Principal Investigator Proposal Budget Startup
Ulysses Balis, M.D.
Peter Higgins, M.D., Ph.D.
Pathology
Internal Medicine
SRB-1 targeted withanolide nanoconjugates for improved targeted therapy of endocrine cancers $86,250
Omer Berenfeld, Ph.D.
Hakan Oral, M.D.
Internal Medicine – Cardiology
Novel real-time intracardiac mapping system to guide ablation in patients with atrial fibrillation $169,609
Mark Cohen, M.D.
Anna Schwendeman, Ph.D.
Surgery – Endocrine
Medicinal Chemistry
SRB-1 targeted withanolide nanoconjugates for improved targeted therapy of endocrine cancers $188,278
Matthew DiMagno, M.D.
Internal Medicine
An Electronic Alert Instrument Shortens Hospital Length of Stay in Acute Pancreatitis $25,000
Kojo Elinitoba-Johnson, M.D.
Megan Lim, M.D., Ph.D.
Pathology
Clinical Genomic Sequence Analysis Software: Automated variant identification from complex genetic datasets $136,095  
Todd Herron, Ph.D.
Jose Jalife, M.D.
Internal Medicine
3D Human Cardiac Tissue for Predicting Oncology Induced Cardiotoxicity $25,000
Joseph Holoshitz, M.D.
Henry Mosberg, Ph.D.
Internal Medicine
Medicinal Optimization of a Shared Epitope Antagonistic Lead Peptidomimetic Compound $25,000
Thiran Jayasundera, M.D.
Matthew Johnson Robertson, Ph.D.
Ophthalmology
Automated Measurement of Changes in Retinal, Retinal Pigment Epithelial, or Chroidal Disease $25,000
Jerome Kalifa, MD. PhD
Internal Med/Cardiology
“Smart Ablation” $25,000
Donna Livant, Ph.D.
Radiation Oncology
Evaluation of PhScN as a Potent Systemic Therapy Combined with Herceptin and/or Radiation for Breast Cancer $187,738
William Meurer, M.D.
Albert Shih, Ph.D.
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Mechanical Engineering
Brain-Cooling Devices for Stroke $10,000
Shahzad Mian, M.D.
Nikos Chronis, Ph.D.
Ophthalmology & Visual Sciences
Mechanical Engineering
Novel real-time intracardiac mapping system to guide ablation in patients with atrial fibrillation $77,196
Kayvan Najarian, Ph.D.
Kenn Oldham, Ph.D.
Emergency Medicine
Computational Medicine & Bioinformatics
Michigan Center for Integrative Research in Critical Care
Mechanical Engineering
A Portable Real-Time Monitoring System for Detection of Cardiovascular Events $24,973
Mukesh Nyati, Ph.D.
Theodore Lawrence, M.D.
Radiation Oncology
Targeting EGFR-dimerization and EGFR-Hsp90 interaction for drug-resistant lung and colorectal cancers $173,544
Dan Orringer, M.D.
Neurosurgery
Taking the Guesswork Out of Brain Surgery $180,000  
Howard Petty, Ph.D.
Ophthalmology
Nanoparticle Therapy in Cancer $25,000
David Raffel, Ph.D.
Radiology
Clinical Translation of 18F-Hydroxphenethylguanidines for Quantifying Cardiac Nerve Density $25,000
Dipankar Ray, Ph.D.
Oncology
Therapeutic Targeting of Mutant KRAS $19,000
Albert Shih, Ph.D.
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Mechanical Engineering
Airway Support Device $99,663
Mohamad Tiba, M.D.
Emergency Medicine
Michigan Center for Integrative Research in Critical Care
Dynamic Response Impedance Volume Evaluation (DRIVE) $92,958  
Hector Valdivia, M.D., Ph.D.
Internal Medicine
Anti-arrhythmic Drugs Based on Natural Peptides $25,000
Thomas Wang, M.D.
Internal Medicine – Gastroenterology
Fluorescent-labeled peptide for targeting early detection of colorectal cancer $86,250
Chris Whitehead, Ph.D.
Judy Leopold, Ph.D.
Radiology
Dual Inhibitor of Receptor Tyrosine and Lipid Kinases $25,000

QUESTIONS?

Have questions about the MTRAC for Life Sciences Innovation Hub? Contact Bradley Martin, Commercialization Program Manager, at bradmart@umich.edu or 734-936-8577.

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