Drug Discovery Guide

The Drug Discovery Guide is an online course designed to introduce you to the exciting world of Drug Discovery. The course is a collaboration between Fast Forward Medical Innovation and Michigan Drug Discovery, with support from Innovation Partnerships.

As you progress through each unit, you will learn the individual steps and critical stages for any drug discovery project, with a particular focus on projects being conducted within the academic environment at the University of Michigan. The lessons in this course focus primarily on small molecule therapeutics, however, many of the points illustrated apply equally to other kinds of drugs, including antibodies and RNA.

Course Goals:

  • Define consistent academic drug discovery terms, concepts, and strategies
  • Outline and describe the critical stages and individual development steps within the academic drug discovery process
  • Identify and access relevant drug discovery resources, including for development, funding, and mentorship

Target Audience:

  • Physician scientists
  • Basic scientists
  • Postdoctoral and other trainees

Course Completion and Obtaining Your Certificate:

This course can be navigated freely, allowing you to select the lesson topics that are especially pertinent to your research today. If you are engaged in drug discovery though, it is recommended that you become cognizant of all the different aspects and considerations involved in the discovery of a novel therapeutic agent by completing all the lessons in this course.

If you wish to obtain a certificate of completion, you must complete each lesson within the four units. Completion includes passing each end of lesson quiz with a score of 80% or higher. Once completed, you will find your certificate available for download/print within the Canvas course.

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Course Outline

Unit 1: Introduction to Drug Discovery

Overview of Drug Discovery
U-M Drug Discovery Ecosystem

Unit 2: Assessing Commercial Potential

Unmet Clinical Need
Market Dynamics
Intellectual Property
Target Product Profile
Commercial Pathway

Unit 3: Advancing Drug Discovery Projects

Target Identification and Validation
Assay Development and Finding Chemical Matter
Lead Selection
Lead Optimization
In Vivo Assays
Candidate Selection (Pharmaceuticals/Chemistry, Manufacturing, and Controls)
Pre-IND Studies

Unit 4: Entering the Clinical Phase

Filing an IND
Clinical Trials

U-M users log in using your Level 1 password and the course will appear on your dashboard. Non-U-M users can log in using the Guest Social option.

Questions?

Contact Samantha Cook, Commercialization Education Program Coordinator, at cooksama@med.umich.edu.

November 9, 2021
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